B1.1
Carbohydrates & Lipids
B1.1 Carbohydrates and Lipids Objectives
Guiding Questions:
In what ways do variations in form allow diversity of function in carbohydrates and lipids?
How do carbohydrates and lipids compare as energy storage compounds?
Linking Questions:
How can compounds synthesized by living organisms accumulate and become carbon sinks?
What are the roles of oxidation and reduction in biological systems?
Learning objectives:
The Importance of Carbon
B1.1.1 Chemical properties of a carbon atom allowing for the formation of diverse compounds upon which life is based: understand the nature of a covalent bond. Students should also understand that a carbon atom can form up to four single bonds or a combination of single and double bonds with other carbon atoms or atoms of other non-metallic elements. Include among the diversity of carbon compounds examples of molecules with branched or unbranched chains and single or multiple rings. NOS: Students should understand that scientific conventions are based on international agreement (SI metric unit prefixes “kilo”, “centi”, “milli”, “micro” and “nano”).
Carbohydrates
B1.1.4 Form and function of monosaccharides: recognize pentoses and hexoses as monosaccharides from molecular diagrams showing them in the ring forms. Use glucose as an example of the link between the properties of a monosaccharide and how it is used, emphasizing solubility, transportability, chemical stability and the yield of energy from oxidation as properties.
B1.1.2 Production of macromolecules by condensation reactions that link monomers to form a polymer: be familiar with examples of polysaccharides (polypeptides and nucleic acids).
B1.1.3 Digestion of polymers into monomers by hydrolysis reactions: Water molecules are split to provide the -H and -OH groups that are incorporated to produce monomers, hence the name of this type of reaction.
B1.1.5 Polysaccharides as energy storage compounds: Include the compact nature of starch in plants and glycogen in animals due to coiling and branching during polymerization, the relative insolubility of these compounds due to large molecular size and the relative ease of adding or removing alpha-glucose monomers by condensation and hydrolysis to build or mobilize energy stores.
B1.1.6 Structure of cellulose related to its function as a structural polysaccharide in plants: Include the alternating orientation of beta-glucose monomers, giving straight chains that can be grouped in bundles and cross-linked with hydrogen bonds.
B1.1.7 Role of glycoproteins in cell–cell recognition: Include ABO antigens as an example.
Lipids
B1.1.8 Hydrophobic properties of lipids: Lipids are substances in living organisms that dissolve in non-polar solvents but are only sparingly soluble in aqueous solvents. Lipids include fats, oils, waxes and steroids.
B1.1.9 Formation of triglycerides and phospholipids by condensation reactions: One glycerol molecule can link three fatty acid molecules or two fatty acid molecules and one phosphate group
B1.1.10 Difference between saturated, monounsaturated and polyunsaturated fatty acids: Include the number of double carbon (C=C) bonds and how this affects melting point. Relate this to the prevalence of different types of fatty acids in oils and fats used for energy storage in plants and endotherms respectively.
B1.1.11 Triglycerides in adipose tissues for energy storage and thermal insulation: understand that the properties of triglycerides make them suited to long-term energy storage functions. Students should be able to relate the use of triglycerides as thermal insulators to body temperature and habitat.
B1.1.12 Formation of phospholipid bilayers as a consequence of the hydrophobic and hydrophilic regions: use and understand the term “amphipathic”.
B1.1.13 Ability of non-polar steroids to pass through the phospholipid bilayer: Include oestradiol and testosterone as examples. Students should be able to identify compounds as steroids from molecular diagrams.
The Importance of Carbon
B1.1.1 Chemical properties of a carbon atom allowing for the formation of diverse compounds upon which life is based: understand the nature of a covalent bond. Students should also understand that a carbon atom can form up to four single bonds or a combination of single and double bonds with other carbon atoms or atoms of other non-metallic elements. Include among the diversity of carbon compounds examples of molecules with branched or unbranched chains and single or multiple rings. NOS: Students should understand that scientific conventions are based on international agreement (SI metric unit prefixes “kilo”, “centi”, “milli”, “micro” and “nano”).
Organic compounds contain carbon and are found in living organisms.
Macromolecules of life include:
carbohydrates,
lipids,
proteins
nucleic acids.
The common chemical elements of life are:
Carbon
Hydrogen
Oxygen
Nitrogen
Life is based on Carbon
Life is based on carbon molecules
carbon has 4 electrons in its outer shell
it can form 4 single bonds or 2 double bonds
carbon based macromolecules of life are very stable
Monosaccharides
carbohydrates:
consist of C, H and O.
provide energy
are composed of simple sugars e.g. glucose
a - Glucose
Monosaccharide = single sugar e.g. glucose, fructose and galactose
Hexose sugar (6 carbons): C6H12O6
Alpha-glucose the -OH group on C1 is orientated in same position as those on C2 and C4.
b - Glucose
beta-glucose the -OH group on C1 is orientated in same position as that on C3.
Ribose
Pentose sugar (C5H10O5)
ribose is the single sugar found in RNA
C2 has an -OH group attached
Deoxyribose
Pentose sugar (C5H10O4)
deoxyribose is the single sugar found in DNA
C2 has an -H group attached
Glucose
Solubility:
dissolves readily in water
has lots of polar hydroxyl groups
can hydrogen-bond with water molecules
Transportability:
Due to solubility in water glucose is transported:
In blood plasma in animals
It can be taken up by cells by facilitated diffusion and secondary active transport
as sucrose dissolved in water in phloem tubes of plants
Stability:
Carbon atoms can form four covalent bonds
Covalent bonds are stable→ giving stability to glucose.
Carbon–carbon bonds forming the ring structure of glucose are strong and stable
Energy from Oxidation
Respiration (oxidative phosphorylation) breaks bonds in glucose to release energy
takes place in mitochondria
Oxidation of glucose removed the many H+ and e- from glucose
C6H12O6 + 6O2 6CO2 + 6H2O (+ energy released)
Metabolism
Anabolism
require energy to synthesise complex molecules from simple molecules
build polymers (macromolecules) from monomers
condensation reaction removing/ forming water
amino acids form proteins
glucose molecules form complex carbohydrates e.g. starch, cellulose and glycogen
fatty acids and glycerol form triglycerides
Catabolism
energy is released when complex molecules form simple molecules
breaks down polymers (macromolecules) into monomers
hydrolysis reaction requiring water to break bonds
proteins broken down to amino acids
complex carbohydrates broken down to glucose
triglycerides broken down to fatty acids and glycerol
Polymerisation (condensation reactions)
Anabolic metabolism builds up polymers from monomers
glucose molecules are joined by condensation reactions
water is removed from hydroxyl groups on C1 and C4 of adjacent glucose molecules
a 1-4 glycosidic bond is created
anabolic processes requiring energy
e.g. formation of starch, cellulose and glycogen
Digestion (Hydrolysis reactions)
catabolic metabolism breaks down polymers to from monomers
maltose molecules are broken down by hydrolysis reactions
water is added to form hydroxyl groups on C1 and C4 of adjacent glucose molecules
the 1-4 glycosidic bond is broken
catabolic processes release energy
e.g. digestion of starch, cellulose and glycogen